Pure Evils who have underwent a mutation changing them into a different form. These villains have experienced a significant physical change to their appearances.
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A
- Aamon (Dark Prince)
- Abaddon the Despoiler
- Abomination (2008 Novelization)
- Abomination (2010 Marvel Animated Universe)
- Acnologia
- Aggregor (Ben 10)
- Aggregor (The Final Key)
- Akihiro Kurata
- Alan Sylvasta
- Albert Wesker
- Aldrich (Dark Souls)
- Aldrich Killian
- Alexia Ashford
- Alien Empera
- All For One
- Alpha (Men In Black)
- Amshel Goldsmith
- Andross
- Aparoid Queen
- Archibald Snatcher
- Arkham (Devil May Cry)
B
C
D
- D'Spayre (Marvel Cinematic Universe)
- Dante Zogratis
- Dark Beast
- Dark Samus (Man on the Internet)
- Darkseid (DC Animated Movie Universe)
- Darkseid (DC Animated Universe)
- Darkseid (DC)
- Darth Krayt
- David Banner (2003 Novelization)
- David Prentiss
- Davros
- Deag Grav
- Deag Ranak
- Derek Clifford Simmons
- Destro
- Dick Hardly
- Dimentio (Super Paper Mario)
- Doctor Doom (2005)
- Dr. Alexander Isaacs
- Dr. Carl Tanner
- Dr. Emilia
- Dragon King
- Drake Merwin
E
F
G
H
J
K
M
- Maestro (Marvel)
- Mahito
- Maker (Ultimate Marvel)
- Maledict
- Malekith the Accursed (2013 Video Game Adaptation)
- Mandarin (Super Robot Monkey Team Hyperforce Go!)
- Manmaruba
- Marshal Yoroi
- Masato Kusaka
- Masato Mishima
- Megabyte
- Mok Swagger
- Momoshiki Ōtsutsuki
- Mother Brain
- Mouth of Sauron
- Mr. Barron
- Mr. Hyde (Van Helsing)
N
P
R
S
- Sabbac (DC Extended Universe)
- Sanctus
- Savanti Romero (TMNT 2003)
- Sebastian Caine
- Secretary Wilson
- Seijiro Inui
- Shadow Lord (Deltora Quest)
- Shiro (Assassination Classroom)
- Shredder (1990s films)
- Shredder (Batman vs. TMNT)
- Skeletor (2002)
- Slender Man (Original Mythos)
- Sonic.exe (original)
- Starscream (Cyberverse)
- Suguru Kamoshida
- Super Buu
- Swartz
- Szayel Aporro Granz
- Sōsuke Aizen
T